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Some show the improvement only in the lumbar spine (lower back) ().

Thus, there is no room for a reasonable person to doubt this role of vitamin K.

Vitamin K supports the carboxylation of matrix Gla protein (MGP), which controls the distribution of calcium in the body and thereby supports the mineralization of bones and teeth, prevents the pathological calcification of soft tissues such as the heart, blood vessels, and kidneys, and supports growth during early development by preventing the premature calcification of growth plates. It has short stature because of calcified growth plates, suffers from osteopenia and spontaneous fractures, and dies within two months due to the rupture of heavily calcified blood vessels.

On this basis, vitamin K is used to prevent hemorrhage in infants and inhibitors of vitamin K recycling such as warfarin and other 4-hydroxycoumarins are used as the principle anticoagulant therapy.

Genetic deficiencies in vitamin K-dependent clotting factors lead to well characterized coagulation disorders, and otherwise fatal cases of bleeding can be rescued with fully carboxylated clotting factors.

The question is whether nutritional doses, which I would define as those under one milligram per day, offer meaningful support to bone health.

Observational studies have associated the use of vitamin K antagonists as anticoagulants with lower bone mineral density (/d) or borderline nutritional (1.5 mg/d) doses of vitamin K that suggest improvements in bone health, but they are not consistently convincing.The vitamin K carboxylase is an enzyme that adds carbon dioxide to the side chains of specific glutamate residues within specific vitamin K-dependent proteins.Once added to a glutamate residue, the carbon dioxide becomes a carboxyl group, so the process is known as carboxylation.Finally, it provides reviews of the available supplements and a searchable database of the vitamin K or have a strong science background, you can click on the buttons that say “click here for a more detailed explanation” in order to expand descriptions that are better suited to your level of expertise.These roles are shown in the shareable infographic below.Estimates of bone strength improved, and less shrinkage occurred in the height of the thoracic spine (mid-back).

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